![]() Therefore, extrapolation of dose from animals to humans needs consideration of body surface area, pharmacokinetics, and physiological time to increase clinical trial safety. This is primarily because the biochemical, functional systems in species vary which in turn alter pharmacokinetics. ![]() It should be emphasized that the common perception of scaling of dose based on the body weight (mg/kg) alone is not the right approach. ![]() Therefore, choosing starting dose of such drugs for research, experiments, or clinical trials in animals and humans is a concern. There are several instances, wherein the initial dose of a particular drug is unavailable in a specific species. Safe and effective drug dosing is necessary, regardless of its purpose of administration.
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